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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“Background: Recent studies in animal models have shown that high methionine intakes induce atherosclerotic changes that may be exacerbated when deficiencies of vitamins B6 , B12 and folate are present.”
Mild Methionine Excess Does Not Affect Thymidylate Synthesis or Inflammation Markers Expression in Human Aortic Endothelial Cells“Depending on specific property of the mutant enzyme molecule some patients respond to very high doses of pyridoxine with decreases of methionine and homocystine and some not.”
“ Vitamin B6 therapy corrected the deficiency and the utilization of administered methionine.”
“B6 in the methylation of nicotinamide is shown by the increased urinary excretion of N1-methylnicotinamide by human subjects, when given methionine plus pyridoxine but not when given only methionine.”
“Thus, PLP infusion could extend the period of MET depletion by MEGC-PEG-rMETase by ∼10-fold in a dose-dependent manner.”
Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate“Calcium oxalate deposition observed in vitamin B6 deficient kidney was completely prevented when fed along with vitamin E or methionine.”
“Abstract The H 4 and M 4 isoenzymes of pig lactate dehydrogenase are both inactivated by reaction with pyridoxal 5′-phosphate.”
“By simultaneous application of methionine and pyridoxine to rats, the urinary xanthurenic acid disappeared completely.10.”
“Results showed MTH, dimethyl disulfide, and dimethyl trisulfide production when Met and PLP were incubated together at 7 degrees C (cheese-aging temperature).”
Short communication: empirical and mechanistic evidence for the role of pyridoxal-5'-phosphate in the generation of methanethiol from methionine.“Covalent binding of L-methionine as an external aldimine to the pyridoxal 5'-phosphate-cofactor in the K41A mutant of O-acetylserine sulfhydrylase from Salmonella typhimurium induces a large conformational change in the protein.”
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