Possible Interaction: Methionine and Vitamin B 12

“One therapeutic approach for tHcy reduction is vitamine supplementation, since folic acid and cobalamine catalyse and enhance metabolism of tHcy to methionine.”

“ Methionine dependence of certain glioma and melanoma cell lines has been linked to alterations in the metabolism of cobalamin (vitamin B12).”

“Stratified analysis by sex showed that the inverse associations between vitamin B12 and methionine intake and colorectal cancer risk were found only among women.”

“ Methionine and vitamin B12 intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids.”

“Methods:We investigated the possible protection against cobalamin inactivation by preoperative methionine loading in patients undergoing nitrous oxide anesthesia.”

“Sourial, N.A. &Brown, A. (1983) Regulation of cobalamin and folate metabolism by methionine in human bone marrow cultures.”

“When in vitro methionine synthase assays were performed in the presence of exogenously added methyl‐cobalamin , specific methionine synthase activity in extracts obtained from homocysteine‐responsive cells was only twofold greater than that observed with extracts prepared from homocysteine‐nonresponsive cells.”

“Treatment (Betaine, folic acid, vitamin B 12 ) induced the disappearance of plasma methionine.”

“In cobalamin deficient E. coli mutant bacteria, methionine under different conditions could either inhibit or potentiate the growth of the organism.”

“Inhalation of nitrous oxidises cobalamin and, in turn, inactivates methionine synthetase which forms methionine from homocysteine and which requires cob[I]alamin as a co-factor.”