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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“ Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine , and leucine.”
Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy.“Glutamine, methionine , tyrosine, and phenylalanine CSF/plasma ratios were elevated with valproate therapy.”
“Treatment of the mice with a combination of L-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz.”
Attenuation of Progressive Hearing Loss in DBA/2J Mice by Reagents that Affect Epigenetic Modifications Is Associated with Up-Regulation of the Zinc Importer Zip4“In this study, we observed a decrease in spine density following L-methionine treatment , which was prevented by co-administration of valproate.”
“Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our earlier work (Tremolizzo et al. and Dong et al.) has shown that L-methionine decreases reelin and GAD67 transcription in mice which is prevented by co-administration of valproate.”
“ VPA induced a 56% reduction in methionine adenosyltransferase activity and a 54% reduction in plasma vitamin B-6.”
“Results: VPA induced a reduction in maternal methionine serum concentration (p < 0.05) caused by a 24% reduction of methionine synthase activity in liver.”
“ Methionine provided in the drinking water of pregnant rats injected with sodium valproate reduced the frequency of resorptions but did not improve embryo growth.”
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