Possible Interaction: Methionine and Tyrosine

“The overall catalytic efficiency (kcat/Km) for methionine and phenylalanine mutants was reduced approximately 3-fold and >6-fold for isoleucine and tyrosine mutants.”

“ MET phosphorylated and activated GSK3B at tyrosine 56 , which decreased the expression of PDL1 by liver cancer cells.”

“There was a linear increase in concentrations of tyrosine , valine, glycine and serine as dietary DLM supplementation level increased.”

“Because true microbial digestion of methionine, cystine, tyrosine , and isoleucine was reduced in the presence of high levels of methionine , we concluded that supplementation of dietary methionine could increase flows of these amino acids to the duodenum.”

“By the supplementation of both methionine and threonine to the high tyrosine diet , the enhancement of brain tyrosine and MHPG-SO4 caused by tyrosine was significantly reduced.”

“Infusion of methionine , tyrosine, phenylalanine, histidine and tryptophan (designated group 1) resulted in significant increases in the uptakes of tyrosine , phenylalanine and histidine.”

“In the latter, enhanced levels of other amino acids including those such as tyrosine and lysine which have no affinity for the methionine carrier inhibit methionine transport.”

“Supplement of methionine to the high tyrosine diet partially alleviated both growth depression and pathological lesions.”

“Transport of l-tyrosine was inhibited by l-phenylalanine and l-methionine but not by d-phenylalanine.”

“ Methionine on the other hand produced a highly significant depression of the activity of this enzyme.(… were significantly decreased after ingestion of glycine, leucine, serine, threonine, methionine, glutamic acid, histidine, phenylalanine, tyrosine , and tryptophan.(d) Serum α-amino nitrogen concentration was … with cystine and lysine, when no change wa...”