Possible Interaction: Methionine and Tretinoin

“Our data showed that 4-day pretreatment of the tumour cells with 10–7 M RA and 10–6 M RA induced an increase in lysis of both cell lines and also increased mICAM-1 expression without having any effect on sICAM-1 levels.”

“This binding was dose and time dependently inhibited by RA (60% inhibition at 10−7 M after 24 h of incubation).”

“When cells are treated with 1, 10, and 100 ng/… of either of these growth factors in combination with 10−5 M retinoic acid , this results in a dose‐dependent synergistic induction of TIMP protein secretion which … greater than the additive effect of the agents by up to fourfold.”

“At a concentration of 10−7 M, RA induces ES cell differentiation into neurons and, conversely, inhibits cardiomyogenesis.”

“Addition of 10−6 M and 3.10−8 M retinoic acid ( RA ) caused a dose-dependent disruption of the seminiferous cords in 14.5-day-old fetal testes, without any change in the 5-bromo-2′-deoxyuridine (BrdU) labeling index of the Sertoli cells.”

“Treatment with 10–6 M RA reduces Hec-Otx mRNA levels in the juvenile to about 12% of normal and is correlated closely with the loss of pharyngeal structures.”

“When embryos in the early shield stage were exposed to RA at concentrations above 10−7 M , the anterior border of Hoxd-4 expression shifted anteriorly in a dose-dependent manner, both in the central nervous system and pharyngeal region.”

“Our present studies using a genetically susceptible mouse strain (B10.A) indicate that the teratogenic actions of exogenous retinoic acid or glucocorticoid in secondary cleft palate induction can be largely reduced or even completely rescued by subsequent administration of methionine.”

“These retinoic acid derivatives inhibited the proliferation of PAM 212 cells at concentrations of 10–5–10–6 M in the culture medium.”

“Measurements of L-methionine uptake revealed a decrease to approximately one-half of that in control cultures after treatment with RA at the concentrations of 5 X 10(-5) M and 10(-4) M.”