Possible Interaction: Methionine and Threonine

“It is found by computer simulated molecular model that the replacement of Thr by Met which has a larger and longer side chain might cause steric hindrance, and change the number of H-bonds.”

“We suggest that loss of hydrophobicity during conversion of methionine to threonine is responsible for the more severe presentation of the first family, whereas maintenance of the hydrophobic nature of the amino acid with conversion to valine resulted in a less severe variant of epidermolysis bullosa simplex.”

“Fasting Met concentration (15 +/- 4 mumol/liter) and the … depressed after 9 days of L & U. Supplementation with Met caused an expected increase of Met concentration (25 +/- 6 ….039 +/- 0.007) and a profound decrease of Thr concentration (119 +/- 28 to 77 +/- 22 ….027 to 0.124 +/- 0.028).”

“These studies confirm Met as the first-limiting amino acid in lupin protein and suggest that Thr becomes limiting when Met is provided in adequate amounts.”

“3) Threonine and methionine are interrelated to each other and form a loop structure.”

“The substitution of methionine with glycine, threonine , or alanine caused a complete loss of the neotropic activity of the peptide.”

“Increasing doses of Thr resulted in increased (P < 0.05) concentrations of methionine , isoleucine, histidine and lysine in whole-body protein.”

“ Threonine was most effective in increasing the degree of parasitaemia but its effect was further enhanced when it was combined with dietary excess of certain other amino acids, notably valine, isoleucine and methionine.”

“The addition of threonine to the methionine supplemental pea protein concentrate significantly reduced the free isoleucine and leucine in the plasma.”

“In rats fed a high tyrosine diet supplemented with methionine plus threonine , liver p-hydroxyphenylpyruvate hydroxylase activity was not higher than that of the 10% casein group, but liver homogentisate oxidase activity increased significantly.”

“When excess tyrosine was included in the 10% casein diet, free tyrosine concentrations in plasma, liver, muscle and brain were extremely elevated, but when the high tyrosine diet was supplemented with extra casein or methionine plus threonine , their plasma and tissues tyrosine concentrations lowered significantly.”

“Most amino acid concentrations declined gradually during the first four weeks of life, but methionine plus one half cystine, phenylalaine, threonine and serine concentrations decreased sharply between two and four weeks.”