Possible Interaction: Methionine and Theophylline

“SummaryThe effect of histamine, pentagastrin and theophylline on the cyclic AMP level was studied in minced gastric tissue and isolated gastric mucosa of …−3 M), alone caused an elevation of the content of cyclic AMP.3.The combination of histamine (6×10−4 M or 10−3 M) … theophylline (….”

“A 30 min pretreatment with theophylline (3 × 10−3 M ) or caffeine (2 × 10−2 M) significantly reduced, in a Ca2+-containing medium, the maximum contractile effect of OA 10−5 and/or 2 × 10−5 M and shortened the relative time to peak tension.”

“ Theophylline inhibited fluid transport in the range 10−3 M to 10−2 M. Cyclic adenosine 3′,5′-monophosphate (cyclic AMP) 3.3× 10−3 M decreased fluid transport only when added to the serosal side.”

“The M current could be reversibly blocked by methylxanthines (caffeine, isobutylmethylxanthine, theophylline ) in the millimolar range, probably because of a direct action on the M channels.”

“ Theophylline at 10−3 M concentration produced a three‐ to fourfold stimulation of both cellular and medium ACE activity.”

“The augmentary effect of theophylline on the adrenaline release was partially reduced by 10−7 M atropine and by 10−6 M propranolol.”