Possible Interaction: Methionine and Tetrodotoxin

“ Methionine reversed the effects of pretreatment with sodium nitroprusside, tetrodotoxin and Nw-oxide-L-arginine, resulting in depolarization of the RMP, and increased amplitude and AUC of contractions in the muscle strip.”

“These agents in concentrations of up to 2 10−7 M modified neither the membrane potential nor the membrane resistance, yet did inhibit the spike potential evoked by direct muscle stimulation in the presence of TTX or by perivascular nerve stimulation.”

“The tissue response was of neurogenic origin as it was blocked by 10−7 M tetrodotoxin.”

“During whole‐cell recordings of the Mauthner cells, applications of 10−6 M tetrodotoxin greatly reduced the frequency and amplitude of the spontaneously occurring synaptic events, which were dominated by Cl−‐dependent inhibitory postsynaptic currents (IPSCs).”

“ Tetrodotoxin , hexamethonium and methionine enkephalin inhibited both the induced VIP release and the secretory response.”

“Reducing the calcium concentration (0.5 mM) or blocking nerve conduction with TTX (3 × 10 −7 M ) prevented the initial excitation and abolished post-inhibitory excitation.”

“ Tetrodotoxin at 3 times 10-7 M raised basal tension in ileal strips in both species and in colonic strips only in the cat.”

“ Tetrodotoxin at 10-5 M caused only small reductions in overshoot.”