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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Methionine and Temozolomide

supplement:

Methionine

Research Papers that Mention the Interaction

A reduction in MET uptake during TMZ treatment predicts a favourable clinical outcome.
European Journal of Nuclear Medicine and Molecular Imaging  •  2005  |  View Paper
Finally, EC-specific KO of Met inhibited vascular transformation, normalized blood vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor growth and prolonged survival in GBM-bearing mice after temozolomide treatment.
The Journal of clinical investigation  •  2016  |  View Paper
For both cell lines, methionine depletion reduces their sensitivity to a range of chemotherapy agents that interface at the level of methionine metabolism, namely temozolomide , cisplatin and methotrexate.
Anticancer research  •  2009  |  View Paper
Increased sensitivity of pancreatic tumor cell lines to temozolomide is shown under methionine stress conditions and is attributed in part to diminished O6-methylguanine-DNA methyltransferase and possibly to inhibition of the cell cycle progression.
Molecular Cancer Therapeutics  •  2005  |  View Paper