supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Methionine
drug:
Temozolomide
Research Papers that Mention the Interaction
“A reduction in MET uptake during TMZ treatment predicts a favourable clinical outcome.”
Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas“Finally, EC-specific KO of Met inhibited vascular transformation, normalized blood vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor growth and prolonged survival in GBM-bearing mice after temozolomide treatment.”
“For both cell lines, methionine depletion reduces their sensitivity to a range of chemotherapy agents that interface at the level of methionine metabolism, namely temozolomide , cisplatin and methotrexate.”
“Increased sensitivity of pancreatic tumor cell lines to temozolomide is shown under methionine stress conditions and is attributed in part to diminished O6-methylguanine-DNA methyltransferase and possibly to inhibition of the cell cycle progression.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback