Possible Interaction: Methionine and Steroids

“However, drugs such as methotrexate and sulfasalazine affect homocysteine metabolism, interfering with vitamin metabolism and absorption.1,3,5 Furthermore, an increased use or … treated with cortisol have plasma homocysteine levels lower than controls.9 Glucocorticoids increase the activity of betaine-homocysteine methyltransferase, which transforms homocysteine in methionine …, steroids …”

“The well known inhibitory effect of M on adrenal 11-hydroxylase is demonstrated by a decrease of serum F and B and a synchronous … 17-OHP soon after drug administration, although plasma ACTH is highly elevated at this time, as well as the marked increase of these steroids … M ….”

“By selectively removing individual essential amino acids from culture medium, we found that 24 h of methionine (Met) deprivation markedly suppressed cell proliferation in enteroids.”

“In contrast, sex steroids only inhibit at pharmacological concentrations, equal to or higher than 10 −5 M .”

“Abstract C1 transfer to the Δ24 bond of 8,24-lanostadien-3β-ol (lanosterol) or of …,19-cyclo-24-lanosten-3β-ol (cycloartenol) was inhibited by triparanol when either of the two steroids was incubated with methionine as the C1 source in a cell-free system from germinating peas.”