Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Methionine and Sirolimus

supplement:

Methionine

Research Papers that Mention the Interaction

In non-infected cells S increased translational controlled tumor protein (TCTP) and phosphatase and tensin homolog (PTEN) proteins while M inhibited mammalian target of rapamycin (mTOR) and TCTP.
PloS one  •  2018  |  View Paper
Under nitrogen fertilization, Leu and Met accumulated in the green morph enhanced the target of rapamycin (TOR) signaling pathway, which consequently increased fecundity by promoting vitellogenin synthesis.
Pest management science  •  2018  |  View Paper
RPM potently inhibited platelet-derived growth factor (PDGF) (IC50=5×10-9 M ) and basic fibroblast growth factor (bFGF) (IC50=8×10-10 M)-induced VSMC DNA synthesis.
Transplantation  •  1995  |  View Paper
Overall, rapamycin showed cytocidal effects at a high concentration of 10−5 M , whereas imatinib did not.
Vascular specialist international  •  2014  |  View Paper
Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.
Applied Microbiology and Biotechnology  •  2004  |  View Paper
ABSTRACT In a chemically defined medium, l-methionine decreased production of rapamycin and increased that of demethylrapamycin.
Antimicrobial Agents and Chemotherapy  •  2000  |  View Paper