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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
drug:
Simvastatin
Research Papers that Mention the Interaction
“In rats, SV decreased progestagens in ovaries, brain and plasma, and plasma FSH in the M (72.4% decrease) and H group (76.6% decrease).”
Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats.“Extracellular accumulation of proteins such as VEGF, OCN, collagenase‐digestive proteins, and noncollagenous proteins was increased in the cells treated with 10−7 M simvastatin , or 10−8 M cerivastatin.”
“Intimal thickening and I M were reduced significantly by low- and high-dose simvastatin compared with vehicle alone.”
“Further assays determine that Simvastatin can inhibit kinase hits EGFR, MET , SRC and HER2 at nanomolar level, which are comparable with those of cognate kinase inhibitors.”
Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome
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