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The American journal of clinical nutrition • 2004 | View Paper
“Mutation of serine to other amino acids with varying side chains: alanine, methionine , leucine, aspartic acid, asparagine, and arginine also resulted in significant activation, indicating a serine-specific inhibitory effect.”
“Compared with methionine alone, the combination of methionine and serine decreased hepatic S-adenosylhomocysteine and homocysteine concentrations and increased hepatic betaine and serine concentrations and betaine-homocysteine S-methyltransferase activity.”
“Fatty liver was also completely prevented by the combination of methionine and serine.”
“Hyperhomocysteinemia induced by choline deprivation was not suppressed by methionine alone and was only partially suppressed by serine alone, whereas it was completely suppressed by a combination of methionine and serine, suggesting a synergistic effect of methionine and serine.”
“In contrast, GAA-induced fatty liver was completely prevented by the combination of methionine and serine.”
Bioscience, biotechnology, and biochemistry • 2011 | View Paper
“The hyperhomocysteinemia induced by a dietary addition of 1% methionine was significantly suppressed by the concurrent addition of 1% glycine or 1.4% serine to the same degree.”
“The hyperhomocysteinemia induced by an intraperitoneal injection with methionine was also suppressed by concurrent injection with glycine or serine , although the effect of serine was significantly greater than that of glycine.”
Izvestiia Akademii nauk. Seriia biologicheskaia • 2005 | View Paper
“We hypothesized that providing additional Met would create a deficiency of Ser and that by simultaneously providing Met and Ser, TS and wool growth could be increased more than by providing Met alone.”
“When hepatocytes from ethanol‐fed rats supplemented with SAM were incubated with methionine plus serine or N‐acetylcysteine, mitochondrial glutathione increased in parallel with cytosol, an effect not observed in cells from ethanol‐fed rats without SAM.”