Possible Interaction: Methionine and Selenomethionine

“Conclusions/Significance This work provides … evidence that the substitution of Met … SeM in proamyloid sequences has a major impact on their self-assembly and toxic properties, suggesting that the SeM pool … play a major role in dictating the allowance and efficiency of a polypeptide chain to undergo toxic polymerization.”

“Cytotoxicity of selenomethionine decreased when the extracellular concentration of methionine or S-adenosylmethionine was increased.”

“The transport of selenomethionine was inhibited by its sulfur analog, methionine , suggesting a common transport mechanism.”

“Exogenous methionine suppresses the biosynthesis of selenomethionine as well as methionine.”

“Methionine analogs including selenomethionine , L-2-amino-4-methoxy-cis but-3-enoic acid and ethionine acted as competitive inhibitors of methionine and as weak substrates when tested in the absence of methionine with [14C]ATP.”

“Production of 1-MeAde by GSS was inhibited by ethionine and selenoethionine , competitive inhibitors of methionine.”

“These data suggest that methionine diverts SeMet from incorporation into general proteins and enhances its conversion to selenocysteine for specific selenium-requiring proteins, such as GSHPx.”

“A ratio of methionine to selenomethionine of 1:10 inhibited induction by approx.”

“The induction and the cytotoxic effects of selenomethionine could be abrogated by simultaneous treatment with methionine.”

“The transport of l-selenomethionine is inhibited by the corresponding sulfur analogue, l-methionine.”

“The selenomethionine represented a little less than 1% of the total amount of methionine.”