Possible Interaction: Methionine and Selenium

“Procyanidins (OPC), methionine (Met) and coenzyme Q10 (Q10) significantly reduced the bioaccessibility of Se.”

“ Methionine levels were higher in cases with selenium depletion than in repletion (P = 0.029).”

“The inhibitory actions of selenium-containing molecules were concentration-dependent (EC(50) values: 8.0-13.2 muM) and were not shared by their sulphur analogs methionine and cystine.”

“The current results suggested that methionine selenium antagonizes oxidative stress, inflammation, and the MAPK pathway, thereby antagonizing the occurrence of necroptosis through multiple mechanisms.”

“At selenium concentration of 10−5 M a modest 18% inhibition of the frequency of transformed glands was detectable at the initiation stage.”

“ Selenium at concentrations of 10−8 M and 10−7 M enhanced the transformation frequency of the glands, acting both at the ‘initiation’ and ‘promotional’ stages.”

“The observed low levels of radiosulfur found in rumen microflora from selenium deficient wethers, indicates that the presence of selenium profoundly affects the rate of methionine metabolism and the distribution of methionine in rumen bacterial and protozoal proteins.”

“Furthermore, the concentrations of glucoraphanin (a sulforaphane precursor) and methionine (a glucoraphanin substrate) slightly changed after Se application.”

“In particular, cysteine, but not methionine , purines, or pyrimidines altered selenium retention and counteracted the growth inhibitory effects of selenium.”

“Cysteine (but not methionine ) supplementation prevented unspecific incorporation of selenium by repressing cysteine biosynthesis.”

“When [75Se]selenomethionine was the source of selenium, the incorporation of selenium into thiolase was inversely proportional to the level of added methionine.”