“However, when M was injected to rats that had received sodium salicylate after each training trial for 7 days, these rats spent less time in target quadrant as compared to M and saline groups.”
“It is concluded that chronic sodium salicylate induces tolerance to anti-nociceptive effects of M and vice versa.”
“When M was injected to sodium salicylate-tolerant rats, a weakened anti-nociceptive effect was seen, indicating cross-tolerance to M. Acute treatment with M also increased TF latency.”