Possible Interaction: Methionine and S-Adenosylmethionine

“In a subset of 15 patients with CSF studies, SAM levels increased in the l-methionine but not in the placebo group (p = 0.07).”

“The authors hypothesized that treatment with l-methionine , the direct metabolic precursor of SAM , might improve AM.”

“Different alterations of the methionine cycle leading to a decrease of S-adenosylmethionine ( SAM ) occur in hepatitis, liver steatosis, liver cirrhosis, and HCC.”

“ Peripheral methionine administration increases SAM and methionine in mouse brain.”

“The availability of B vitamins and methionine regulate SAM generation.”

“ SAMe acts as a co-repressor of methionine synthesis genes and also inhibits the folate cycle, whereas SAH blocks homocystine remethylation7.”

“In this study, we demonstrate that methionine restriction leads to a >10-fold decrease in CBS protein levels, and pulse proteolysis studies reveal that binding of AdoMet stabilizes the protein against degradation by approximately 12 kcal/mol.”

“High levels of methionine may also perturb intracellular S-adenosyl methionine pools and have an effect on the methylation of DNA and proteins.”

“Our data suggest that in contrast to synovium, downstream methylation reactions involving methionine and the biosynthesis of S-adenosylmethionine ( SAM ) could be reduced in nodule tissue.”

“We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) … SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 μM. In cells, methionine … SAM levels below this dissociation constant … a SAMTOR-dependent fashion.”

“The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans.”