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Last Updated: 2 years ago

Possible Interaction: Methionine and S-Adenosylmethionine

supplement:

Methionine

Research Papers that Mention the Interaction

In a subset of 15 patients with CSF studies, SAM levels increased in the l-methionine but not in the placebo group (p = 0.07).
The authors hypothesized that treatment with l-methionine , the direct metabolic precursor of SAM , might improve AM.
Neurology  •  2004  |  View Paper
Different alterations of the methionine cycle leading to a decrease of S-adenosylmethionine ( SAM ) occur in hepatitis, liver steatosis, liver cirrhosis, and HCC.
Medicina  •  2019  |  View Paper
Peripheral methionine administration increases SAM and methionine in mouse brain.
Neurochemistry International  •  2018  |  View Paper
The availability of B vitamins and methionine regulate SAM generation.
Autoimmunity  •  2014  |  View Paper
SAMe acts as a co-repressor of methionine synthesis genes and also inhibits the folate cycle, whereas SAH blocks homocystine remethylation7.
Nature Medicine  •  2013  |  View Paper
In this study, we demonstrate that methionine restriction leads to a >10-fold decrease in CBS protein levels, and pulse proteolysis studies reveal that binding of AdoMet stabilizes the protein against degradation by approximately 12 kcal/mol.
Proceedings of the National Academy of Sciences of the United States of America  •  2006  |  View Paper
High levels of methionine may also perturb intracellular S-adenosyl methionine pools and have an effect on the methylation of DNA and proteins.
The Journal of nutrition  •  2006  |  View Paper
Our data suggest that in contrast to synovium, downstream methylation reactions involving methionine and the biosynthesis of S-adenosylmethionine ( SAM ) could be reduced in nodule tissue.
Clinical and experimental rheumatology  •  2017  |  View Paper
We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) … SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 μM. In cells, methionine … SAM levels below this dissociation constant … a SAMTOR-dependent fashion.
Science  •  2017  |  View Paper
The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans.
Nutrition & Diabetes  •  2016  |  View Paper
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