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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
supplement:
Quinidine
Research Papers that Mention the Interaction
“Further analysis indicated a multifactorial action potential prolongation by quinidine : (1) decreasing fast repolarization with IC50 of 1.1·10-6 M ; (2) reducing maximum upstroke velocity with IC50 of 2.6·10-6M; and (3) suppressing spontaneous activity with EC50 of 3.8·10-6M.”
Action potential-based MEA platform for in vitro screening of drug-induced cardiotoxicity using human iPSCs and rat neonatal myocytes.“Elevating perfusion solution K+ content from 3 &mgr;M to 5 m M reduced the QT-widening effects of quinidine and flecainide (P < 0.05).”
Does QT Widening in the Langendorff-perfused Rat Heart Represent the Effect of Repolarization Delay or Conduction Slowing?“ Quinidine also inhibited both the positive inotropic response and concomitant increase in tissue N-methylated phospholipids observed upon l-methionine perfusion of rat heart.”
“3 Procaine, procainamide and quinidine , at 5 × 10−5 M to 10−3 M , depolarized the cells to around − 30 mV and reduced APA and Vmax.”
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