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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
drug:
Platinum
Research Papers that Mention the Interaction
“The intratumoral platinum concentration was higher in combination with methionine starvation than cisplatin alone, possibly accounting for at least part of the modulating effect of methionine depletion.”
Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice.“This inhibition of aminoisobutyric acid and methionine was dependent on the concentration of platinum.”
Inhibition of amino acid transport by cis-diamminedichloroplatinum(II) derivatives in L1210 murine leukemia cells.“ Methionine may enhance mutagenicity of the platinum drug by increasing activities of some enzymes associated with error-prone DNA repair.”
Mutagenicity of platinum coordination complexes in Salmonella typhimurium.“Thus it appears that in the enzyme systems studied, the methionine acts as a strong ligand for platinum.”
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