Possible Interaction: Methionine and Phospholipids

“Substitution of Asn-1 with Met caused a reduction in enzymatic activity and membrane-damaging activity of PLA(2) toward phospholipid vesicles , while sphingomyelin exerted an inhibitory effect on the biological activities of native and mutated PLA(2).”

“At a higher concentration of 10−7 M , this phospholipid induced more rapid, but not greater, contraction.”

“The uptake of methionine and transfer of methyl group to phospholipid in the cells by methionine were remarkably higher than those by S-adenosylmethionine.”

“1 H-NMR resonance of both the methionine methyl group (met-27) and the aromatic envelope of glucagon are broadened by the phospolipid , indicating that the C-terminal region and the aromatic residues are involved in the interaction with the phospholipid.”

“A significant incorporation of methyl groups into phospholipids occurred not only with methionine but also with SAM.”

“A tenfold increase of I4C incorporated into phospholipids was found in both groups after methionine was added.”

“The rate of phosphatidylcholine formation via phospholipid N-methylation approximately doubled when L-methionine was added at concentrations similar to that in rat plasma.”

“ Methionine lowers the concentrations of serum triglycerides and phospholipids only slightly but substantially lowers serum cholesterol concentration.”

“It is suggested that a definite increase in phospholipide turnover following a single large dose of choline or methionine may indicate fatty infiltration of the liver, and perhaps provide an indication of the need for treatment with lipotropic substances.”

“Indeed, in experimental animals with fatty infiltration of the liver induced by diet, it has been shown by the use of radiophosphorus that choline or methionine will cause an increase in the phospholipide turnover in the liver (4, 5).”