Possible Interaction: Methionine and Phenylalanine

“Substitution of Tyr194 with Phe significantly suppresses the activation of FAK by Met.”

“Substitution of a methionine in the natural epitope by a tyrosine or a phenylalanine at that position, as dictated by the motif, resulted in a peptide with an affinity for binding to mAb A16 about 50 times higher than that of the natural epitope.”

“ L-phenylalanine reduced L-methionine uptake (25-69%) in 70% of studies.”

“The net rate of brain accumulation of L-methionine ranged from 0.42 to 2.89 (average 1.28) nmol/min/cc, and decreased by 27.5–91.2% (average 53.9%) after L-phenylalanine.”

“Efflux of transported methionine is temperature dependent, and is greatly increased in the presence of unlabeled L- or D-methionine or L-phenylalanine , but not in the presence of L-arginine.”

“ Methionine and phenylalanine were inhibitory.”

“For both the parenteral and enteral groups, phenylalanine oxidation (% of dose) decreased linearly (P < 0.01) as methionine intake increased and then became low and unchanging.”

“Amination to methionine was greater than that to phenylalanine (P<0·01), suggesting a mechanism for preferentially protecting the former.”

“The viability of this preparation can be maintained for 1h as indicated by morphological findings, competitive inhibition between L-phenylalanine and L-methionine , and the transport of L-phenylalanine against a concentration gradient.”

“Reduction of the levels … lysine, threonine and methionine from the generous levels characteristic of a diet containing 240 g protein from skim milk/kg, to the requirement levels … separately in the presence of the generous levels of all the other amino acids, resulted in a twofold increase in phenylalanine ….”