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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
drug:
Paclitaxel
Research Papers that Mention the Interaction
“Whilst the mechanism responsible for this remains uncertain, the increased activity of paclitaxel against methionine dependent cells in conjunction with the decreased activity against Hs-27 cells suggests that methionine depletion strategies may enhance the therapeutic index of paclitaxel.”
Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro.“Moreover, in βTub, the massive displacement observed in M and S loops significantly alters the binding site of microtubule targeting drugs like Taxol.”
“ Taxol is a potent microtubule stabilizing agent that selectively blocks cells in the G2 and M phases of the cell cycle and is cytotoxic in a time-concentration dependent manner.”
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