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“Since MET deprivation can individually potentiate the different chemotherapeutic agents used in the 48-hour combined regimen of 5-FU, leucovorin and oxaliplatin (FOLFOX) regimen, we initiated a feasibility study associating dietary MET restriction with the FOLFOX regimen in patients with metastatic colorectal cancer.”
“In the absence of NaCl, in water, the initial rate at which L‐met concentration decreases with cisplatin, oxaliplatin and carboplatin is 0.25±0.007, 0.057±0.01 and 0.17±0.02 mM h−1, respectively.”