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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Methionine
drug:
Onartuzumab
Research Papers that Mention the Interaction
“Because onartuzumab , a monovalent antibody to MET, blocks HGF-induced MET activation, the addition of onartuzumab to erlotinib may improve therapeutic efficacy.”
“ Onartuzumab reduced phospho-MET levels, inhibited MET ubiquitination, and consequently restored MET protein levels.”
Combining Onartuzumab with Erlotinib Inhibits Growth of Non–Small Cell Lung Cancer with Activating EGFR Mutations and HGF Overexpression“ Onartuzumab , a humanized, monovalent monoclonal anti-MET antibody, antagonizes MET signaling by inhibiting binding of its ligand, hepatocyte growth factor (HGF).”
“Indeed, combined targeting of MET with onartuzumab and EGFR with erlotinib in a clinical trial prolonged progression-free survival and overall survival in patients with lung cancer expressing high levels of MET [7].”
“Targeting MET has inherent difficulties, although onartuzumab was designed to circumvent some of these, at least.”
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