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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
drug:
Nitrous Acid
Research Papers that Mention the Interaction
“Inhalation of nitrous oxidises cobalamin and, in turn, inactivates methionine synthetase which forms methionine from homocysteine and which requires cob[I]alamin as a co-factor.”
Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat.“Treatment … nitrous oxide-exposed monkeys … repetitive doses of methionine (100 mg/kg 10, 12 and 14 hr after methanol) reversed the effects of nitrous oxide on formate oxidation, resulting in a marked decrease in blood formate levels and an increase in the rate of [14C]O2 formation from methanol.”
“The administration of methionine to nitrous oxide-treated rats increased hepatic Ado-Met concentrations and restored hepatic H4folate levels and formate oxidation to control values but did not reverse the inhibition of methionine synthetase.”
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