Possible Interaction: Methionine and Nicotine

“The inactive orthlogues … kinase Eph and MET , namely vab-1 and RB2088 respectively, the temperature sensitive constitutively active form of KRAS, SD551 (let-60; … c-CBL equivalent mutants in sli-1 (PS2728, PS1258, and MT13032) when subjected to chronic exposure of nicotine resulted in a significant … capacity and fertility.”

“Moreover, the detection of sub G1 phase and TUNEL assay demonstrated that nicotine significantly induced apoptotic cell death at 10−2 M concentration.”

“Concentrations of cytochalasin B (10−4 M) and colchicine 10−3 M ) which markedly reduced or blocked the liberation of 3H-norepinephrine evoked by nicotine and 60 mM potassium did not interfere with the effect of tyramine.”

“ Nicotine produced concentration dependent relaxation when preparations were precontracted by phenylephrine ( 10−5 M).”

“The contractile response to nicotine was abolished even though tissue histamine levels (determined in the heart) and the response to histamine were unchanged.2.(+)-Chlorpheniramine 10−8 M reduced contractions caused by histamine, whereas a concentration of 10−5 M was necessary for a significant antagonism of nicotine effects.”

“ Nicotine (10–7 M) also stimulated CRH release and this stimulation was completely blocked by 10–6 M but not by 10–7 M of the nicotinic receptor blocker, hexamethonium (HEX).”

“The methyl group of nicotine has been shown to participate in transmethylation reactions involving methionine (3) and choline (8).”