Possible Interaction: Methionine and Neuropeptide Y

“This is because, in the presence of the Y1 receptor antagonist, BIBP3226 10‑7 M ), the stimulatory effect of NPY on VSMC migration was blocked.”

“In cells that expressed Y1, Y2, and Y5 receptors, NPY bimodally stimulated migration and proliferation with a 2‐fold increase at 10−12 M and 10−8 M (high‐ and low‐affinity peaks, respectively).”

“ Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10—7 and 10—6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation.”

“ NPY (10−9 to 10−6 M) reduced the degree of cAMP accumulation achieved by 10−7 M isoproterenol in a dose dependend manner by 10 to maximally 48%.”

“ NPY (10–8, 3×10–8 and 10–7 M) potentiated in …-dependent way the arterial contraction in response to exogenous noradrenaline ( 10–8–10–4 M ) at 30°C but not at 37°C, and it increased … response to ATP (10–4–10–2 M) at both temperatures.”