Possible Interaction: Methionine and Morphine

“For 16% of M+ group, the use of M had a bad signification about their disease, but 52% of M- group thought that if morphine was used in their cases, the meaning would be very bad.”

“The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001).”

“RESULTS: Morphine consumption in the first 48 h was decreased in the M and MC groups.”

“During the last ten years hyperalgesia (H), allodynia (A) and myoclonia M ) has been reported at an increased frequency in human beings treated with morphine.”

“In contrast to the adenosine agonists, … of the spinal cord tissue to 10−5 M morphine significantly reduced the potassium-stimulated release of substance P. Pretreatment of the slices with 10−5 M … or 8-phenyltheophylline did not significantly attenuate the inhibition of substance P release produced by morphine.”

“At frequencies of 0.3, 1, and 3 Hz, but not at 10 Hz, morphine in concentrations of 10−7–10−5 M depressed the stimulation-induced overflow of tritium.”

“Previous results have shown that treatment of rats with morphine during the neonatal period can influence development of peptide transport system-1 (PTS-1), the blood-brain barrier transport system for Tyr-MIF-1 and methionine enkephalin.”

“Jhamandas, K., Yaksh, T. L., Go, V. L. W. (1984) Acuteandchronic morphine modifies the in vivo release of methionine enkephalinlike immunoreactivity from the cat spinal cord and brain.”

“RX800 M produced a dose‐dependent antagonism of the antinociceptive effect of morphine , but did not antagonize the response to U50488H.”

“ Morphine (5 × 10−5 M and 2 × 10−4 M), nalbuphine (2 × 10–4 M), and butorphanol (4 × 10–6 M) significantly decreased release of NE.”