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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Methionine and Monoamine Oxidase Inhibitors

Research Papers that Mention the Interaction

IN 1961 POLLIN, CARDON and KETY’ reported that a proportion of chronic schizophrenic patients who received methionine given in conjunction with a monoamine oxidase inhibitor showed an acute psychosis followed in some cases by an amelioration of their chronic schizophrenic symptoms.
Journal of psychiatric research  •  1971  |  View Paper
The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients.
International pharmacopsychiatry  •  1977  |  View Paper
Large doses of methionine prescribed with amine oxidase inhibitors produced behavioural changes in schizophrenics (Pollin, Cardon, and Kety, 1961; Park, Baldessarini, and Kety, 1965), and it has been suggested that there is an aetiological link between schizophrenia and disorders of transmethylation-for example, in the review by Smythies (1967).
Journal of neurology, neurosurgery, and psychiatry  •  1969  |  View Paper
ORAL administration of a large amount of methionine to schizophrenic patients who had been treated with a monoamine oxidase inhibitor ( MAOI ) was reported to produce psychic symptoms which have been interpreted either as an intensification of schizophrenic symptoms or as superimposed toxic symptoms1–4.
Nature  •  1967  |  View Paper
Pollin, Cardon and Kety3 observed hyporeflexia and extensive mood changes in schizophrenic patients who received tryptophan, or methionine in addition to a monoamine oxidase inhibitor.
The New England journal of medicine  •  1962  |  View Paper