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Discover Supplement-Drug Interactions

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Possible Interaction: Methionine and Methotrexate



Research Papers that Mention the Interaction

Remethylation of Hcy into methionine and DNA methylation are also affected by MTX treatment.
International journal of cancer  •  2003  |  View Paper
Long-term low-dose methotrexate treatment (7.5-25 mg) inhibits production of thymidylate, purines, and methionine and leads to intracellulary accumulation of adenosin.
Zeitschrift fur Gastroenterologie  •  1999  |  View Paper
In both groups, plasma homocysteine increased and methionine decreased following administration of MTX.
The delay in the recovery of methionine in the intravenous 6MP group after MTX infusion is probably the result of an increased demand on methyl groups during 6MP infusion.
Biochemical pharmacology  •  1996  |  View Paper
The methionine depletion may interfere with the antileukemic effect of MTX.
Cancer research  •  1991  |  View Paper
Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase.
Cancer research  •  1989  |  View Paper
In vitro and in vivo evidence suggests that methionine may be useful to potentiate and homocysteine to reduce methotrexate action.
The Journal of clinical investigation  •  1969  |  View Paper
Exposure to methotrexate in the diet resulted in increases in the expression of a multidrug efflux transporter gene ( MET ; CG30344) in the Malpighian tubules.
Archives of insect biochemistry and physiology  •  2010  |  View Paper
MTX also blocked the transfer of the beta carbon from serine into methionine.
MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
If methotrexate is administered in conjunction with either nicotinamide or methionine , the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.
General pharmacology  •  1999  |  View Paper
Methionine at a high concentration (1.5 mg/ml) enhanced the cell-killing action of methotrexate under conditions of delayed drug addition and did not diminish it when added with the drug simultaneously.
Polish journal of pharmacology and pharmacy  •  1981  |  View Paper
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