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Last Updated: a year ago

Possible Interaction: Methionine and Methotrexate



Research Papers that Mention the Interaction

3) Results: MTX significantly reduced de novo deoxythymidylate (dTMP) and methionine biosyntheses from mitochondrial-derived formate in cells, mouse liver, and bone marrow, supporting our postulation that MTX depletes mitochondrial 1C supply.
International journal of molecular sciences  •  2021  |  View Paper
Pharmacokinetic studies show that MMCMs M ) with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other treatments.
Science China Life Sciences  •  2014  |  View Paper
For both cell lines, methionine depletion reduces their sensitivity to a range of chemotherapy agents that interface at the level of methionine metabolism, namely temozolomide, cisplatin and methotrexate.
Anticancer research  •  2009  |  View Paper
The authors conclude that methionine metabolism influences MTX neurotoxicity.
Neurology  •  2005  |  View Paper
Remethylation of Hcy into methionine and DNA methylation are also affected by MTX treatment.
International journal of cancer  •  2003  |  View Paper
The median leukocyte count was higher for M (73×109/l) than for the other treatment regimens (T: 27×109/l, T+C: 37×109/l, MP: 24×109/l, MP+MTX : 30×109/l, E: 31×109/l).
Annals of Hematology  •  2000  |  View Paper
Long-term low-dose methotrexate treatment (7.5-25 mg) inhibits production of thymidylate, purines, and methionine and leads to intracellulary accumulation of adenosin.
Zeitschrift fur Gastroenterologie  •  1999  |  View Paper
In both groups, plasma homocysteine increased and methionine decreased following administration of MTX.
The delay in the recovery of methionine in the intravenous 6MP group after MTX infusion is probably the result of an increased demand on methyl groups during 6MP infusion.
Biochemical pharmacology  •  1996  |  View Paper
The methionine depletion may interfere with the antileukemic effect of MTX.
Cancer research  •  1991  |  View Paper
Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase.
Cancer research  •  1989  |  View Paper
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