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International journal of cancer • 2003 | View Paper
“Long-term low-dose methotrexate treatment (7.5-25 mg) inhibits production of thymidylate, purines, and methionine and leads to intracellulary accumulation of adenosin.”
Zeitschrift fur Gastroenterologie • 1999 | View Paper
“In both groups, plasma homocysteine increased and methionine decreased following administration of MTX.”
“The delay in the recovery of methionine in the intravenous 6MP group after MTX infusion is probably the result of an increased demand on methyl groups during 6MP infusion.”
“ Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase.”
The Journal of clinical investigation • 1969 | View Paper
“Exposure to methotrexate in the diet resulted in increases in the expression of a multidrug efflux transporter gene ( MET ; CG30344) in the Malpighian tubules.”
Cancer Chemotherapy and Pharmacology • 2004 | View Paper
“If methotrexate is administered in conjunction with either nicotinamide or methionine , the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.”
“ Methionine at a high concentration (1.5 mg/ml) enhanced the cell-killing action of methotrexate under conditions of delayed drug addition and did not diminish it when added with the drug simultaneously.”