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Discover Supplement-Drug Interactions
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Last Updated: 5 months ago
supplement:
Methionine
drug:
Methotrexate
Research Papers that Mention the Interaction
“Remethylation of Hcy into methionine and DNA methylation are also affected by MTX treatment.”
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.“In both groups, plasma homocysteine increased and methionine decreased following administration of MTX.”
“The delay in the recovery of methionine in the intravenous 6MP group after MTX infusion is probably the result of an increased demand on methyl groups during 6MP infusion.”
“The methionine depletion may interfere with the antileukemic effect of MTX.”
“ Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase.”
“In vitro and in vivo evidence suggests that methionine may be useful to potentiate and homocysteine to reduce methotrexate action.”
“Exposure to methotrexate in the diet resulted in increases in the expression of a multidrug efflux transporter gene ( MET ; CG30344) in the Malpighian tubules.”
Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae.“If methotrexate is administered in conjunction with either nicotinamide or methionine , the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.”
“ MTX also blocked the transfer of the beta carbon from serine into methionine.”
“ MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells.”
“ Methionine at a high concentration (1.5 mg/ml) enhanced the cell-killing action of methotrexate under conditions of delayed drug addition and did not diminish it when added with the drug simultaneously.”
“However, if cells were deprived of methionine for 6 hr before exposure to methotrexate , the methotrexate effect was reduced.”
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