Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Methionine and Folate

supplement:

Methionine

supplement:

Folate

Research Papers that Mention the Interaction

At the same time, folate deficiency accelerates alcohol-induced changes in hepatic methionine metabolism while promoting enhanced oxidative liver injury and the histopathology of ALD.
The Journal of nutrition  •  2002  |  View Paper
Methionine starvation leads to depleted methionine levels in cells, modifies methylation reactions, lowers glutathione levels and alters folate distribution and leads to a tumor-selective cell cycle arrest in late-S/G2.
Anticancer research  •  1996  |  View Paper
The inverse association of methionine was modified by plasma folate concentrations (OR [95% CI] for highest/lowest versus lowest/lowest tertile of plasma methionine/folate concentrations 0.39 [0.24, 0.64], Pinteraction = 0.06).
Epidemiology  •  2016  |  View Paper
Folate metabolism regulates changing of amino acids (homocysteine and methionine ), purine and pyrimidine synthesis and DNA methylation.
Ginekologia polska  •  2013  |  View Paper
Background: Recent studies in animal models have shown that high methionine intakes induce atherosclerotic changes that may be exacerbated when deficiencies of vitamins B6, B12 and folate are present.
Annals of Nutrition and Metabolism  •  2009  |  View Paper
In this review, we will explore the impact of folate deprivation on the regulation of the methionine cycle and exhaustively describe different biochemical reactions that are implicated in the regulation of homocysteine elimination and that folate deficiency influences in AD neuropathology.
Vitamins and hormones  •  2008  |  View Paper
Comparing the highest quartile of intake with the lowest, the authors found lower risks of all NHL associated with increasing intakes of folate and methionine.
American journal of epidemiology  •  2008  |  View Paper
Background/Aims: Folate deficiency disturbs hepatic methionine metabolism and promotes the development of steatohepatitis in animal models.
Liver international : official journal of the International Association for the Study of the Liver  •  2007  |  View Paper
It is conceivable that an association with folate may be modified by alcohol and/or methionine intake given that alcohol consumption and low methionine intakes both increase dietary folate requirements.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation  •  2006  |  View Paper
A more … association between folate intake and breast cancer risk (OR, 0.47; 95% CI, 0.25-0.88; … trend, 0.01) was observed among women who consumed high levels of folate cofactors ( methionine , vitamin B(12), and vitamin B(6)) than … intake levels of these nutrients were low.
Thus, our study adds additional support to the protective role of dietary folate in breast carcinogenesis and suggests further that the effect of folate may be modified by dietary intake of methionine , vitamin B(12), and vitamin B(6).
Cancer research  •  2001  |  View Paper
Show More