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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“Further analysis revealed that EGCG at low doses specifically inhibited HGF/SF-induced tyrosine phosphorylation of Met but not epidermal growth factor (EGF)-induced phosphorylation of EGF receptor (EGFR).”
“On the other hand, high-dose EGCG decreased both Met and EGFR proteins.”
Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion“ EGCG significantly inhibited HGF-induced phosphorylation of Met and cell growth, invasion and expression of MMP-2 and MMP-9.”
“treatment with high doses (100–2000 mg/kg) of EGCG significantly decreased the intestinal levels of SAM and SAH, decreased the plasma levels of methionine , and elevated the plasma levels of homocysteine.”
“ EGCG added up to 4 h after the addition of HGF … cell scattering and reduced the HGF‐induced phosphorylation of c‐Met , Akt, and Erk, suggesting that EGCG could act both by preventing activation of c‐… by HGF and by attenuating the activity of pathways already induced by HGF.”
“Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein.”
“The inhibitory effect of EGCG on the methionine consumption was more prominent, especially at higher concentrations.”
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