Possible Interaction: Methionine and D-Methionine

“ Urinary methionine excretion was 20 times higher after ingestion of D-methionine than after ingestion of L-methionine or L-methionine sulfoxide, with the increase due to D-methionine excretion.”

“Substitution of the L-methionine at the C terminus of peptides with D-methionine markedly increased the effectiveness of the peptides.”

“Another set of experiments with jejunal brush-border membrane vesicles showed that D-methionine uptake is dependent on a Na+ gradient and is significantly inhibited by L-methionine and L-proline, but not by beta-alanine and alpha-methylaminoisobutyric acid.”

“ D-Methionine was found to inhibit L-methionine uptake by intestinal rings according to fully noncompetitive kinetics (Ki = 45 mM).”

“When 4.7 mmoles/kg of D-methionine were administered, total brain methionine and cysteine increased by 4and 3-fold respectively, the former peaking at 1.5 hr and the latter at 2.5 hr post-injection.”

“The average daily gain and feed conversion ratio of birds fed L-methionine were higher than those fed D-methionine (P<0.05) from the time of hatching till 21 days.”

“The methionine analogues, D-methionine and DL-ethionine, competitively inhibited the incorporation of the methyl group from methionine into flagellar NML, but had no effect on the incorporation of L-[U-14C]lysine.”

“The incorporation of d-methionine is inhibited by l-methionine.”

“Oxidized casein hydrolysate and methionine sulfone inhibited the activity of D-methionine.”