Possible Interaction: Methionine and Buthionine Sulfoximine

“In addition, cells grown in the presence of the glutamine synthetase inhibitor, methionine sulphoximine , showed a marked decrease in proliferation.”

“Additionally, the pharmacological inhibition of GS activity with methionine sulfoximine abolished the effect of GUO in reducing d-aspartate release and cellular damage evoked by OGD.”

“Inhibition of GS with methionine sulfoximine resulted in a decrease of extracellular 13N-glutamine accompanied by an increase of 13N-ammonia as compared with control.”

“Inhibition of GS with methionine sulfoximine resulted in a decrease of extracellular 13N-glutamine accompanied by an increase of 13N-ammonia as compared with control.”

“Using methionine sulfoximine as an inhibitor of the γ-glutamyl cycle, the early rate was reduced to 10.0 nmol/g/min and the later rate to 3.7 nmol/g/min.”

“On the other hand, pretreatment with various concentrations of methionine sulfoximine reduced the glutamine synthetase activity in ammonia-treated RGM-1 cells, and prevented the induction of apoptosis and the reduction in intracellular ATP levels in a dose-dependent manner.”

“When the cultured astrocytes were incubated with methionine sulfoximine , the fructose-1,6-bisphosphatase activity increased.”

“In the hippocampal formation the decrease of glutamine levels during l-methionine sulfoximine treatment was more pronounced than in the frontal cortex, and was accompanied by a delayed decline of extracellular glutamate concentrations.”

“Pretreatment with methionine sulfoximine , an inhibitor of glutamine synthetase, blocked the ammonia‐induced collapse of Δψm, suggesting a role of glutamine in this process.”

“Pretreatment with 3 mM methionine sulfoximine , an inhibitor of glutamine synthetase, also suppressed free radical formation by 5 mM NH4Cl.”