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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methionine
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“ ADMA release by cultured endothelial cells was significantly increased in the presence of methionine or homocysteine.”
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.“Results: At … h after methionine loading, … and ADMA levels (35.4±10.9 and 0.80±0.13 μmol/L, mean ±SD) were significantly higher than the corresponding values … at noon the day before (15.6±7.4 and 0.63±0.10 μmol/L, both p<0.001).”
“We found that the production of ADMA by human endothelial cells is upregulated in the presence of methionine or homocysteine and inhibited by either of the methyltransferase inhibitors S-adenosylhomocysteine, adenosine dialdehyde, or cycloleucine.”
“Plasma ADMA and SDMA decreased transiently after the methionine load.”
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia
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