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Try: Ginkgo, Methotrexate, Glucosamine

Last Updated: 3 years ago

Possible Interaction: Methimazole and Glutamic Acid

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drug:

Methimazole

supplement:

Glutamic Acid

Research Papers that Mention the Interaction

“In vitro, methimazole was found to inhibit the vitamin K-dependent step in coagulation factor synthesis, the gamma-carboxylation of glutamic acid , and, in addition, the vitamin K epoxide reductase, an enzyme related to the carboxylation reaction.”

Severe gastrointestinal haemorrhage after methimazole intake

Clinical endocrinology • 2011 | View Paper

“Both were found in vitro to inhibit the vitamin K dependent step in clotting factor synthesis, the gamma-carboxylation of glutamic acid with 50 per cent inhibitory concentrations of 2 mM for propylthiouracil and 0.1 mM for methimazole.”

MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA

Drug metabolism and drug interactions • 1988 | View Paper

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