Possible Interaction: Methamphetamine and Oxytocin

“Last, oxytocin is known to modulate stress responsivity via regulation of the autonomic nervous system, which is dysregulated in METH users.”

“Based on their shared capacity to enhance sociability, we hypothesized that both methamphetamine and alcohol would increase plasma oxytocin levels.”

“Our data suggest that vagus nerve signalling is required for the inhibitory effects of peripherally administered oxytocin on METH self-administration and reinstatement, and that this vagal dependency is partially mediated by sex and drug withdrawal.”

“ Oxytocin treatment robustly attenuated METH intake in both sexes, and SDV entirely prevented the suppressant effect of oxytocin (0.3 mg/kg) on METH intake, and partially prevented the effects of 1 mg/kg oxytocin in both sexes.”

“The preclinical research corroborates the clinical findings that systemic administration of oxytocin decreases relapse to cocaine, methamphetamine , heroin, and alcohol seeking (reviewed in [2]).”

“The nucleus accumbens core (NAcc) has been identified as an important site for oxytocin to inhibit METH behaviours, although previous findings suggest that the effects of oxytocin in the NAcc are mediated by receptors other than the oxytocin receptor (OTR).”

“CONCLUSIONS Ox tocin de creases met h de mand and seeking in both sexes, and these effects depend on oxytocin signaling in the nucleus accumbens.”

“In both male and female rats, meth demand predicted reinstatement of meth seeking, and systemic oxytocin decreased demand for meth and attenuated reinstatement to meth seeking.”

“ Oxytocin was most effective at decreasing meth demand and seeking in rats with the strongest motivation for drug.”

“Here, we examined whether OT exposure during adolescence might subsequently inhibit METH self‐administration in adulthood.”

“However, rats pre‐treated with OT responded significantly less for METH under a PR reinforcement schedule, and showed reduced METH‐primed reinstatement with the 1 mg/kg prime.”

“The neuropeptide oxytocin OT ), given acutely, reduces self‐administration of the psychostimulant drug methamphetamine ( METH).”

“The neuropeptide oxytocin attenuates reward and abuse for the psychostimulant methamphetamine ( METH).”

“ MA drinking led to significant decreases in oxytocin , but not vasopressin, in the paraventricular nucleus of the hypothalamus.”

“These findings highlight an important modulatory effect of oxytocin in the NAc core on relapse to METH seeking.”