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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methamphetamine
supplement:
Ginseng
Research Papers that Mention the Interaction
“Interestingly, ginseng also inhibited the appearance of the recurrent phenomenon (reappearance of the sensitized state was observed at the time of readministration of MAP and cocaine even after a 30-day discontinuation of drug administration) of the effect of MAP and cocaine.”
“On the other hand, behavioral sensitization (reverse tolerance to ambulation-accelerating effect) to morphine, methamphetamine (MAP) and cocaine was also inhibited by ginseng.”
“The conditioned place preference of MAP and cocaine was completely blocked by ginseng.”
[Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants].“Interestingly, ginseng also inhibited the appearance of the recurrent phenomenon (reappearance of the sensitized state was observed at the time of readministration of methamphetamine and cocaine even after a 30-day discontinuation of drug administration) of the effect of methamphetamine and cocaine.”
“On the other hand, behavior sensitization (reverse tolerance to their ambulation-accelerating effect) to morphine, methamphetamine and cocaine was also inhibited by ginseng.”
“The conditioned place preference of methamphetamine and cocaine was completely blocked by ginseng.”
“Intraperitoneal administration of ginseng total saponin (GTS, 200 mg/kg of body weight) prior to and during chronic administration of methamphetamine inhibited the development of reverse tolerance.”
Blockade by ginseng total saponin of the development of methamphetamine reverse tolerance and dopamine receptor supersensitivity in mice.“After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP, although GE itself did not affect the spontaneous motor activity of the naive mice.”
“These results provide evidence that GE may be useful for prevention and therapy of the adverse action of MAP.”
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