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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Methadone and St John's Wort

supplement:

St John's Wort

Research Papers that Mention the Interaction

St. John's wort … methadone blood levels and induce withdrawal symptoms which, if not correctly identified and handled (by changing the antidepressant or by increasing the methadone … the patient, lead to resumption of illicit drug uses, or be a risk factor for discontinuation of the methadone or antidepressant treatment.
Pharmacopsychiatry  •  2003  |  View Paper
Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases … alprazolam, amitriptyline, atorvastatin, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone , midazolam, nifedipine, omeprazole, oral contraceptives, …, talinolol, verapamil, voriconazole and warfarin.
Drugs  •  2012  |  View Paper