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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methadone
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“When applied to the bathing solution, methadone was found to block IK, I Na and I Ca.”
Methadone block of K+ current in squid giant fiber lobe neurons“Since calcium is a critical regulator of cellular function, the calcium-antagonist action of methadone and l-acetylmethadol may prove to be important in mediating some of their pharmacologic and toxicologic effects.”
“ Abstract Methadone at 10 −3 M preferentially inhibits Ca uptake by a heavy (2000 – 8000 x G) fraction of rabbit skeletal muscle and has little effect on the standard light sarcoplasmic reticulum fraction.”
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