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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Methadone and Adrenocorticotropic Hormone

drug:

Methadone

supplement:

Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

“The acute administration of methadone in nonpregnant mice produced an increase in ACTH level throughout the estrous cycle whereas subchronic treatment reduced ACTH level by 51%.”
Acute and subchronic effects of methadone on the blood hormonal levels of pregnant and nonpregnant Charles River CD-1 mice.
Pediatric pharmacology  •  1983  |  View Paper
“Morphine, meperidine and methadone thus apparently cause a release of ACTH from the hypophysis.”
The effect of certain analgesic drugs and adrenal cortical hormones on the brain of normal and hypophysectomized rats as measured by the thiobarbituric acid reagent.
The Journal of pharmacology and experimental therapeutics  •  1951  |  View Paper
“Cortisone and ACTH , however, markedly reduced the effect of morphine or methadone upon this reaction, while DCA enhanced it.”
The effect of cortisone, desoxycorticosterone, and adrenocorticotrophic hormone upon the responses of animals to analgesic drugs.
The Journal of pharmacology and experimental therapeutics  •  1951  |  View Paper