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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methacholine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“In hypercholesterolemic subjects, endothelium-dependent vasodilation to methacholine was augmented by coinfusion of vitamin C (P = .001); in contrast, endothelium-independent vasodilation to nitroprusside and verapamil were not affected by coinfusion of vitamin C (P = .8 and P = .3, respectively).”
Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia.“In diabetic subjects, endothelium-dependent vasodilation to methacholine was augmented by simultaneous infusion of vitamin C (P = 0.002); in contrast, endothelium-independent vasodilation to nitroprusside and to verapamil were not affected by concomitant infusion of vitamin C (P = 0.9 and P = 0.4, respectively).”
“Pretreatment with ascorbic acid prevented the significant alteration in airway responsiveness to methacholine aerosol (65 +/- 13 mg/ml, p less than 0.04).”
“ Ascorbic acid at 24 mg/min significantly improved the forearm blood flow response to methacholine in hypertensive patients with a peak response of 16.1+/-7.1 mL. min(-1).”
“However, both the duration and intensity of the bronchoconstriction induced by methacholine aerosol (10 mg/ml for 30 sec) were significantly reduced by prior administration of ascorbic acid.”
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