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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methacholine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“… methacholine, … calcium concentration.4.Both at normal and lowered calcium concentrations the inhibitory action of methacholine was larger from 0–5 than from 5–10 min … media containing high K+-high Na+ or normal K+-low Na+ caused noradrenaline outputs somewhat smaller than those after high K+-low Na+.”
Muscarinic inhibition of potassium-induced noradrenaline release and its dependence on the calcium concentration“Histamine (30 microM), MCH (1 microM), GTP-gamma-S (100 microM) and phorbol dibutyrate (1 microM) all potentiated contractions induced by 1 microM Ca++ in skinned fibers.”
“At 1 microM, Bay K 8644 (an L‐type Ca2+ channel activator) increased 2‐fold the secretory response to DTC plus methacholine (2746 ng of catecholamines).”
“Addition of methacholine to the surrounding buffer increased flow of ASL and potential difference across the mucosa and lowered pH, calcium , sodium, and chloride concentrations.”
“Exposure to 10 μm methacholine increases calcium sensitivity in all fibers that initially require 3.3 μm Ca2+ or greater for 50% activation.”
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