“At the end of the light on period corresponding … peak of the circadian rhythm in ACTH, administration of rMCH but not NEI leads … a decrease in ACTH levels while MCH is not effective during the light off period … the cycle (i.e. when basal ACTH levels are already low).”
“Taken together, these data indicate that rMCH may act as a central corticotropin inhibitory factor involved in the circadian rhythmicity of plasma ACTH levels and that NEI antagonizes its action.”
“ rMCH (63 or 210 nmoles) prevents the rise in ACTH release while NEI alone does not modify the stress response.”