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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Metformin and Vitamin B 12

supplement:

Vitamin B 12

Research Papers that Mention the Interaction

OBJECTIVE Of patients who are prescribed metformin , 10-30% have evidence of reduced vitamin B12 absorption.
Diabetes care  •  2000  |  View Paper
In conclusion, metformin treatment increased tHcy levels and decreased levels of vitamin B12 and folate.
It is known that the metabolism of homocysteine (Hcy) depends on the vitamins B6, B12 and folate, and furthermore that metformin reduces serum vitamin B12 levels.
Scandinavian journal of clinical and laboratory investigation  •  1997  |  View Paper
Although vitamin B12 malabsorption is relatively common with long-term metformin treatment, we think this is the first reported case of megaloblastic anaemia.
British medical journal  •  1980  |  View Paper
The absorption of folic acid and vitamin B12 is importantly decreased by the prolongued use of metformin , which is the first choice drug in uncomplicated diabetes, thus these two nutrients have been found deficient in the disease and most probably need to be supplemented regularly.
Endocrine, metabolic & immune disorders drug targets  •  2015  |  View Paper
Metformin interferes with mucosal-cell intracellular calcium handling, thus disrupting calcium-dependent absorption of vitamin B12 in the ileum (30).
Ten percent to 30% of patients receiving long-term metformin therapy develop vitamin B12 malabsorption, as indicated by decreased concentrations of total vitamin B12 and its bioavailable form, holotranscobalamin (2, 30).
Annals of Internal Medicine  •  2002  |  View Paper
Spearman’s correlation showed a significant negative correlation between cobalamin and increased dose of metformin and a significant positive correlation between TCSS and increased dose of metformin.
Scientific reports  •  2021  |  View Paper
Patients taking doses of metformin more than 1000 mg had lower levels of vitamin B12.
Patients taking doses of metformin more than 1000 mg had lower levels of vitamin B12.
Saudi medical journal  •  2021  |  View Paper
It has been reported that long-term metformin use might reduce serum vitamin B12 levels.
The Pan African medical journal  •  2020  |  View Paper
Second, we would like to caution that metformin reduces intestinal absorption of vitamin B12 in up to 30% of metformin‐treated patients and lowers serum vitamin B12 concentrations by 5% to 10%.
Journal of Medical Virology  •  2020  |  View Paper
Metformin can decrease vitamin B12 and folate concentrations.
The Journal of clinical endocrinology and metabolism  •  2020  |  View Paper
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