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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Metformin and Tyrosine

supplement:

Tyrosine

Research Papers that Mention the Interaction

In contrast, metformin in pharmacological concentration (1-10 mmol/L) further inhibited tyrosine phosphorylation of IR?,
Acta pharmacologica Sinica  •  2003  |  View Paper
Metformin (1 micro …/ml) increased IR tyrosine phosphorylation by 78% (P = 0.0007) in 30 min in human hepatocytes and Huh7 cells and increased IRS-2 but not …-1 activation, and the downstream increase in deoxyglucose uptake was mediated via increased translocation of GLUT-1 to the plasma membrane.
The Journal of clinical endocrinology and metabolism  •  2003  |  View Paper
Treatment with metformin was able to increase the tyrosine phosphorylation of IR and IRS‐1 by 100 and 90% respectively.
British journal of pharmacology  •  2002  |  View Paper
The results demonstrate coupling energy for metformin with amino acids F, W, H and Y , because of the interaction between the metformin dication and the electron cloud of π orbitals.
Frontiers in Pharmacology  •  2020  |  View Paper