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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In contrast, metformin in pharmacological concentration (1-10 mmol/L) further inhibited tyrosine phosphorylation of IR?,”
Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells.“ Metformin (1 micro …/ml) increased IR tyrosine phosphorylation by 78% (P = 0.0007) in 30 min in human hepatocytes and Huh7 cells and increased IRS-2 but not …-1 activation, and the downstream increase in deoxyglucose uptake was mediated via increased translocation of GLUT-1 to the plasma membrane.”
“Treatment with metformin was able to increase the tyrosine phosphorylation of IR and IRS‐1 by 100 and 90% respectively.”
Metformin enhances insulin signalling in insulin‐dependent and ‐independent pathways in insulin resistant muscle cells“The results demonstrate coupling energy for metformin with amino acids F, W, H and Y , because of the interaction between the metformin dication and the electron cloud of π orbitals.”
Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation
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