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Last Updated: 2 years ago

Possible Interaction: Metformin and Tretinoin

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drug:

Metformin

supplement:

Tretinoin

Research Papers that Mention the Interaction

“Further analysis revealed that a strong synergistic effect existed between metformin and all-trans retinoic acid (ATRA) during APL cell maturation and that metformin induced the hyperphosphorylation of extracellular signal-regulated kinase (ERK) in APL cells.”

Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway.

Biochemical and biophysical research communications • 2012 | View Paper

“While oral retinoids have been reported to positively impact AN, improvement of AN with metformin has been reported in only two prior cases.”

Improvement of acanthosis nigricans on isotretinoin and metformin.

Journal of drugs in dermatology : JDD • 2003 | View Paper

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