Possible Interaction: Metformin and Taurine

“Further metabolic profiling of these cells using 1H-Nuclear Magnetic Resonance spectroscopy revealed significant modulation in taurine and histidine levels in resistant cells developed in the presence of metformin.”

“In short, the present results … that the addition of TAU to a treatment of diabetes with CAP or CAP-MET, and sometimes to one with MET , will lead to a gain in protective potency against changes in indices of glucose metabolism and of renal functional impairment and oxidative stress.”

“Furthermore, the concurrent administration of MET and TAU to the diabetic rats led to brain values of indices of oxidative stress that were lower than those attained with MET alone, although generally not to a statistically significant degree.”

“The present results suggest that MET and TAU are more protective against diabetes-induced metabolic and oxidative alterations when used together than separately, probably because of complementary actions.”

“When used together, TAU was found to enhance the antioxidant actions of MET both in the plasma and RBCs.”

“Overall, this study finds that MET and TAU can offer the same pattern of protection as INS against diabetes-related metabolic and biochemical changes relevant to renal function, and that TAU can enhance the protective actions of MET on diabetes–related renal biochemical and functional alterations.”

“Supplementing MET with TAU enhanced the actions of MET to different extents.”