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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Metformin and Sphingosine 1-Phosphate

Research Papers that Mention the Interaction

Together, the findings reported here show that hypoxia-induced SPHK1 expression and downstream S1P signaling promote ovarian cancer progression and that tumors with high expression of SPHK1 or S1P levels might have increased sensitivity to the cytotoxic effects of metformin.
Molecular Cancer Research  •  2019  |  View Paper