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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Using metformin and a mitochondria/complex I (mCI)-targeted analog of metformin (norMitoMet) in experimental pairs of …-activated protein kinase (AMPK)-, serine hydroxymethyltransferase 2 (SHMT2)- and mCI-null cells, we provide evidence that metformin … SAM :SAH ratio-related methylation capacity by targeting … mitochondrial one-carbon flux and CI activity.”
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism“To understand how metformin limits folate in bacteria, the authors investigated methionine metabolism and found that metformin impaired the methionine cycle and was associated with increased levels of both S-adenosylmethionine (SAMe) and S-adenosylhomocysteine (SAH).”
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